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MOTS-c can be incredibly useful for metabolic health, but the way you run it matters. I cover four common mistakes that can leave you feeling like the peptide did nothing—or even made you feel worse. I explain why dosing too frequently may work against the signal you’re trying to create, why oral, nasal, and sublingual forms may not deliver what you expect, and why peptide quality and sourcing matter beyond a simple purity percentage. I also explain why sequencing matters, especially when SS-31 may need to come before MOTS-c. My goal is to help you recognize whether the issue is the peptide itself or how your protocol is being structured.
Dr. Jones, DC, Clips:
📍Chapters
0:00 – Intro
2:12 – Mistake #1: Dosing Too Frequently
6:54 – Mistake #2: Using the Wrong Delivery Method
8:57 – Mistake #3: Poor Quality & Sourcing
11:49 – Mistake #4: Wrong Sequencing
14:04 – Identifying What Went Wrong With Your Protocol
*DISCLAIMER*
The content in this video is intended for educational and informational purposes only and is not a substitute for individualized medical advice, diagnosis, or treatment. Always consult with a qualified, licensed healthcare provider before beginning or modifying any treatment, medication, or wellness program discussed herein. Dr. Jones and his affiliates expressly disclaim any liability for direct or indirect loss, injury, or damage incurred as a result of reliance on the information presented. This video may discuss prescription medications, including GLP-1 receptor agonists, peptides, and other metabolic therapies, some of which may involve off-label use, compounded formulations, or investigational drugs not yet approved by the U.S. Food and Drug Administration (FDA). The inclusion of any compound—whether FDA-approved, compounded under Section 503A of the FD&C Act, or used under state-specific medical discretion—does not constitute an endorsement, promotion, or medical recommendation. The legal status of compounded medications may vary by jurisdiction and is subject to change under federal and state law, as well as FDA enforcement discretion. This content is not intended to advertise or promote any specific drug, product, or provider. Statements about potential benefits or outcomes are general in nature and have not been evaluated by the FDA unless otherwise noted. No guarantees of effectiveness or safety are made, and all therapies discussed should be considered in the context of individual medical oversight. Patient stories, testimonials, before-and-after imagery, or references to clinical results represent real cases managed by licensed professionals. Individual results vary, and outcomes are not guaranteed. Where applicable, patient names, likenesses, voices, or identifying details have been changed or anonymized in compliance with HIPAA, state privacy laws, and professional ethical guidelines. All patient media is used with written consent or has been sufficiently de-identified to meet legal standards. Footage or imagery used may depict real patients or actors and should not be interpreted as typical or universal results. By viewing this video, you acknowledge that you are voluntarily assuming full responsibility for any personal decisions made based on the content presented. This video is for general public consumption and is not intended to create a doctor-patient relationship. For personalized advice or a treatment plan, consult a licensed healthcare provider directly.
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Is there a clear way of "knowing for sure" MOTS-c is working? (Or even real!)
@DrJonesDC Hello there.
I ordered Mots- c from your clinic and have a few questions.
1. Is it ok to take this on the same day as my TESTOSTERONE injection and TIRZEPATIDE ?
2. How many days apart should it be if it's twice a week?
3. Do I need to take it during training days?
4. Do I need to take it same two days every week?
5. What happens if I miss the day and don't realize it until the next day or day after that?
New subscriber, I want to start Mot-c but am unsure as to the reconstitution, amount to inject in each shot. Etc…
About a month in on Peptides.
Reta – 2mg/once a week (for health benefits. Im fairly thin, so I am not trying to lose too much weight/muscle)
Tesa – 1mg/ M-F (Sleep and visceral far loss)
KLOW – 2mg/ twice a week (skin repair and to reduce inflammation, recovery)
MOTS C – 2mg/ twice a week (preworkout boost, energy increase while working out)
Trying to figure out where i can fit in NAD+.
I’m training for several 1/2 marathons, 10k’s and 5k’s. I do not want to reduce my energy levels. I need both endurance, strength and speed.
So, if I go for 2 times a week, can it be monday and wed? Or does it need to be more spaced out?
But WHY does front-loading work? I would love to know the mechanism as to why this only works at the beginning.
Ist bottle no probs Mon, Thursday 5mg, 2nd bottle massive welt on my belly MON then thursday did my glute same issue can you do IM?
I am every other day M-F
I don’t know what was so difficult about this discussion. He informed you to use the 10mg at a more limited frequency per week.
Every other day with NAD after a 6 week run of ss31 is the sweet spot. Me and my gang run this protocol and its perfect.
I keep hearing different opinions about peptides. What do you think is the most misunderstood thing about them?
I read reconstituting with BAC saline water is better for welts and itchiness, any merit to this?
So you didn't actually answer the question: I started on MOTS-C without running SS31 first. So should I be switching to SS and then come back to MOTS?
Hey Doc, I commend you for putting these videos together and also for replying the way you do. Instead of just a thumbs up, you put thought into the replies. Thank you.
I'm starting off by taking SS-31 because I was on chemotherapy for cancer and chemotherapy has shown to wreck your mitochondria.
Thanks!
Why are you give medical advice when you Chiropractor, you guys are not trained in endocrinology or internal medicine. no fellowship in any real medicine. WTF.
Mot-c is definitely a peptide that should always be filtered to help (reduce) not eliminate full mast cell reaction risk.
Isn’t this similar to NAD+?
I wanna use it just because of the beautiful blue color 😀
I inject once a week early in the morning at 2mg
I'm confused about the insulin sensitivity and resistance with mots c. I tried bpc and TB on a diabetic foot ulcer pre and post surgery and recovery was amazing
I don’t feel like I got the answer to how many days I should be injecting….10mg once a week?
I take it 1 to 2hr before workout, 20 to 25units basically pre workout but only once a week for a month then off for 2 to 3weeks
6mg a week mon wed fri 2mg per injection. Only has moderate effect on receptors. Run 4-6 weeks then 4-8 weeks off to to re sensitise metabolic axis
Mots is a fantastic stack with Reta if you've leveled off
I’m sure I overdosed on MOTSC.
10mg a week? Thats my entire vial. So I have to buy a vial a week and take half one day and the other half a few days later. You’re telling me to go from 10 units for 5 days with 2 days off to 50 units twice a week?
I use mots-c Tuesday/Saturday for almost 2months but i dont know whats the effect for my body and once a week for reta.. until now i dont know whats it do for my body because i dont feel any changes😁😁
Running Mot-C 2x weekly without a break since February 2026. Post MI it made a HUGE difference in my cardio days. If I skip it, I hit a wall, which is probably my body's Mot-C production catching up. This is one peptide I have run strategically, with excellent results.
How is he a weight loss Dr??? He is a chiropractor!! Its dishonest.
I did a preparation with SS31 daily for 4 weeks (later adding NAD+ as well) before starting MOTS-C. Currently I still take 4mg SS31 (day 1) then 100mg NAD+ (day 2) and 5mg MOTS-C (day 3) then repeat. This comes up to around 2,33 times MOTS-C per week, would this still be reasonable?
If the peptide signal only lasts a few hours after administration, and we are aiming for changes due to this signal
Would a more frequent and lower dose be a better choice since the amount at once is less at the receptor site and also still has hours within the same day of administration to desensitize that receptor site ?
5mg 3x a week. M/W/F…..
This is the best universal dosing guide across the board. Anything over 5mg has a massive diminishing returns. Not much evidence anything over 5mg is worth it.
@drKjoseph1 did a video where more than once a week is recommended at low dose vs your 10mg once a week.
So my question is actually more about ss31. How long should a person run ss31 before starting with mots-c?
AICAR IS WAY BETTER! MOTS C IS OVER HYPED
Started with Mots first felt great for a few weeks and bam 💥 felt tired the next week! Now I’m getting ready to do ss-31 so that i can do it correctly.
Had to stop using Motsc because it kept giving me big welts on my stomach
But whats better? MOTS-c or NAD+ if you can only use one?
I have personally went through this. I found a protocol that keeps all my Peptides in high receptive state. Instead of doing 5 days on, 2 days off one your everyday peptides, i do 4 days on, 3 days off. For the ones i take 2 to 3x a week like NAD+, tb-500 or mots-c, i do those 2x in those 4 days. The first day and the last day of those 4 days. This WORKS. Tuesday morning, 8 shots, Weds morning, 5, Thursday morning, 5, then Friday morning 8 shots. Then 3 days off. The only one i take 5x a week is ghk-cu at night.
Apologies for asking question offline subject…. have you heard about Lilly 's Foundayo ,daily oral pill? Does it still kill the food noise,ect.
I'm on zepbound, maintaining and don't mind the injections, but a pill might be a nice change…if it works.
Thank you, jan